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Ex-Manchester United boss Jose Mourinho welcomes his old club to Turkey when his Fenerbahce side host the Red Devils on Thursday.
Odds Now's Brad Walker has put up an intriguing 13/1 bet-builder ahead of the clash.
Turkish hosts Fenerbahce come into matchday three having taken four points from their first two matches against Union Saint-Gilloise and FC Twente.
Mourinho's men are also unbeaten in their last four in all competitions and will take confidence from their recent home record.
Not only have Sarı Kanaryalar lost just once in their last nine at the Şükrü Saracoğlu Stadium, but Fenerbahce are also unbeaten in their last nine home fixtures in the Europa League.
Compare with opponents Manchester United, who picked up their first win in five against Brentford at Old Trafford on Saturday.
The Red Devils' struggles have been well-documented this season, but their form on the road has been particularly troubling.
Their 3-0 victory at Southampton last month remains their sole victory in an away fixture this term.
Erik Ten Hag's men have also failed to inspire with draws to FC Twente and Porto in their opening two matches in this competition.
Both of these sides tend to be involved in entertaining affairs.
Four of Fenerbahce's last five matches have seen both teams find the back of the net, as has been the case in three of United's last five.
The Turkish club always score at least once in home matches - they've not failed to score in front of their own fans in their last 11 matches on home turf.
Meanwhile, United have scored in 16 of their last 17 away games in the Europa League - the only blemish being a 3-0 loss to Sevilla in April last year.
The Bosnian striker has been in great form during the initial stages of this season, where he has already racked up an impressive tally of nine goals and two assists.
His record against the English club will also provide a boost in confidence - Dzeko has found the net nine times against the Red Devils during his time with Wolfsburg, Manchester City and AS Roma particularly.
Given United's poor defensive record, which has seen them keep just one clean sheet in their last five, Fenerbahce's star striker will be confident of bagging once again in this one.