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Manchester United return to Old Trafford after two positive results on the road, but can they continue momentum against bottom-placed Southampton?
Odds Now's Brad Walker (@brad_TWalker) has dived into the match-up and put up a tasty 17/2 bet-builder ahead of kick-off on Thursday evening.
Even by Manchester United's standards, failure to win this one would be calamitous.
The hosts come into the game on the back of impressive performances - and results - against big-hitters Liverpool and Arsenal.
Ruben Amorim's side put in their best performance of the season in the 2-2 draw at Anfield before following it up with a hard-spirited penalty shootout victory at the Emirates, despite playing over an hour with 10 men.
Add in the fact Southampton are on course to be the worst Premier League side of all-time and it's hard to envisage anything other than a home win in this one.
The Portuguese international has often been the subject of intense criticism since arriving at Old Trafford, but no one can fault his overall performance during the past 12 months.
He was a rare shining light in the recent 3-0 loss to Bournemouth at Old Trafford, registering five shots in total. Three were on target.
Suspension ruled him out for the next home game against Newcastle, which also ended in defeat, but the 30-year-old comes into this one having found the back of the net at the Emirates last weekend.
Given Southampton have conceded 70 shots on goal in their last four league outings, it's hard to envisage Fernandes not being heavily-involved again.
Former Manchester City defender Taylor Harwood-Bellis has already served a suspension for receiving five yellow cards this season, but that hasn't hastened the England centre-back's tenacity.
The 22-year-old's name has since gone in the book in Southampton's most recent two league outings, taking him up to a joint-second highest seven cards this term.
Harwood-Bellis will be at the heart of a Saints defence facing a bustling Man. United attack which could smell blood on Thursday evening as they look to continue their momentum.
The big pitch at Old Trafford can be a daunting proposition at the best of times but, given Southampton's miserable run of form, the visiting backline could be in for another long night here.
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